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Samarium Sm 153 lexidronam (Quadramet)

Indications: - bone pain due to bone metastasis - metastatic prostate cancer [2] Dosage: - intravenous Injection: - single-dose glass vials containing 3 mL with 5550 MBq (150 mCi) of samarium-153 at calibration [3] Mechanism of action: - taken up by bone, releasing radiation into the bone, thus reducing tumor burden & associated pain

General

samarium [Sm] radiopharmaceutical

Database Correlations

PUBCHEM correlations

References

  1. Mayo Clinic: Samarium Sm 153 Lexidronam (Intravenous Route) http://www.mayoclinic.org/drugs-supplements/samarium-sm-153-lexidronam-intravenous-route/description/drg-20065896
  2. Sartor O Overview of Samarium Sm 153 Lexidronam in the Treatment of Painful Metastatic Bone Disease. Rev Urol 2004; 8(Suppl 10) S3-S12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472939/
  3. RxList: Quadramet http://www.rxlist.com/quadramet-drug.htm