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sal-like protein 2; zinc finger protein 795; zinc finger protein SALL2; zinc finger protein Spalt-2; sal-2; hsal2 (SALL2, KIAA0360, SAL2, ZNF795)
Function:
- probable transcription factor
Structure:
- belongs to the sal C2H2-type Zn+2-finger protein family
- contains 7 C2H2-type Zn+2 fingers
Compartment: nucleus (probable)
Expression:
- highest levels in adult brain (in different areas)
- lower levels in heart; very low levels in kidney & pancreas
- in fetal brain exclusively in pontine nuclei
General
C2H2 type zinc finger protein
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 1007 aa
MW = 105 kD
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {135-139}
proline-rich region
SITE: 158-170
MOTIF: proline residue (SEVERAL)
serine-rich region {256-265}
MOTIF: serine residue (SEVERAL)
Zn finger C2H2-type
SITE: 373-395
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 401-423
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S609}
Thr phosphorylation site {T616}
Ser phosphorylation site {S623}
Zn finger C2H2-type
SITE: 631-653
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 659-681
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 691-713
EFFECTOR-BOUND: Zn+2
glutamate-rich region {764-775}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S797}
Ser phosphorylation site {S802}
Ser phosphorylation site {S806}
alanine-rich region {816-821}
MOTIF: alanine residue (SEVERAL)
proline-rich region
SITE: 838-843
MOTIF: proline residue (SEVERAL)
Zn finger C2H2-type
SITE: 911-933
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 940-964
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 602219
UniProt Q9Y467
Entrez Gene 6297
Kegg hsa:6297
References
UniProt :accession Q9Y467