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salivary acidic proline-rich phosphoprotein 1/2; Db-s; PRP-1/PRP-2; parotid acidic protein; Pa; parotid double-band protein; parotid isoelectric focusing variant protein; PIF-S; parotid proline-rich protein 1/2; Pr1/Pr2; protein C; contains: salivary acidic proline-rich phosphoprotein 3/4; Db-F; PIF-F; PRP-3/PRP-4; protein A; peptide P-C (PRH1)
Function:
- PRP's act as highly potent inhibitors of crystal growth of Ca+2 phosphates
- they provide a protective & reparative environment for dental enamel
- proteolytically cleaved; PRP-2, PRP-1, PIF-S & Db-S yield PRP-4, PRP-3 (protein A), PIF-F & Db-F, respectively
- hexuronic acid is linked to Ser-33 in about 40% of the polypeptides
Compartment: secreted
Polymorphism:
- allele PRH2-1 is also known as PR-1 or protein C, & allele PRH2-3 as PR-1'
- the PRH1-DB allele (~ 16% of the population) has an insertion of 21 repeated amino-acids compared to the more frequent PRH1-PIF allele (68%)
- in contrast to all other PRH1 & PRH2 alleles, the PRH1-PA allele (16%) is not proteolytically cleaved
General
phosphoprotein
proline-rich protein
salivary protein
Properties
SIZE: entity length = 166 aa
MW = 17 kD
COMPARTMENT: saliva
MOTIF: signal sequence {1-16}
domain {17-46}
MOTIF: Ser phosphorylation site {S24}
Ser phosphorylation site {S33}
Ser glycosylation site {S33}
Ser phosphorylation site {S38}
Ser glycosylation site {S38}
Database Correlations
OMIM correlations
UniProt P02810
LOCUS-LINK correlations
KEGG correlations
References
- UniProt :accession P02810
- SHMPD; Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PRH1
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PRH2