salinomycin; salinomycinum (Coxistac)

Indications: - treatment of breast cancer (possibly) Laboratory: - salinomycin in specimen Mechanism of action: - selectively toxic to breast cancer stem cells

General

antineoplastic agent (chemotherapeutic agent) oxysterol; hydroxysterol

References

- Gupta PB et al Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009 Aug 21; 138:645 PMID: 19682730 http://dx.doi.org/10.1016/j.cell.2009.06.034