Search
SAFE study
Design:
1) double blind trial
2) 7000 surgical or medical intensive care unit patients
3) 64% with mechanical ventilation
4) 44% with organ failure (1 or more organs)
Fluid resuscitation with normal saline or 4% albumin
Results:
1) all cause mortality same in both groups at 21 days
2) a trend toward improved outcome with 4% albumin observed in septic patients
3) a trend toward improved outcome with normal saline observed in head trauma patients
General
clinical trial
References
- Journal Watch 24(13):104, 2004
Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R;
SAFE Study Investigators.
A comparison of albumin and saline for fluid resuscitation
in the intensive care unit.
N Engl J Med. 2004 May 27;350(22):2247-56.
PMID: 15163774
- Cook D.
Is albumin safe?
N Engl J Med. 2004 May 27;350(22):2294-6. No abstract available.
PMID: 15163781