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SAFB-like transcription modulator (modulator of estrogen-induced transcription, SLTM, MET)
Function:
- when overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- contains 1 RRM (RNA recognition motif) domain
- contains 1 SAP domain
Compartment:
- nucleus
- detected in punctate structures (putative)
Alternative splicing: named isoforms=2
General
nuclear protein
phosphoprotein
RNA-binding protein
Properties
SIZE: entity length = 1034 aa
MW = 117 kD
COMPARTMENT: cell nucleus
MOTIF: SAP {22-56}
Ser phosphorylation site {S93}
Ser phosphorylation site {S97}
glutamate-rich region {108-239}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S139}
Ser phosphorylation site {S289}
RNP motif
NAME: RNP motif
SITE: 384-462
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
Ser phosphorylation site {S421}
Ser phosphorylation site {S551}
Ser phosphorylation site {S553}
glutamate-rich region {569-906}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S590}
coiled coil {609-728}
Ser phosphorylation site {S1002}
Database Correlations
UniProt Q9NWH9
PFAM correlations
References
UniProt :accession Q9NWH9