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Sad1/unc-84-like protein 2 (Rab5-interacting protein, Rab5IP, UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2)
Function:
- interacts with RAB5A
Structure:
- contains 1 Unc84 (SUN) domain
- Unc84 domain may play a role in the nuclear anchoring &/or migration
Compartment:
- nucleus membrane
- endosome membrane
Expression:
- widely expressed
- highly expressed in heart, lung & muscle
- weakly expressed in fetal heart
Pathology:
- slightly overexpressed in some heart tissues from patients with congenital heart defects
Note: uncertain whether Met-1 or Met-50 is the initiator
Related
protein C20orf24 (Rab5-interacting protein, RIP5, C20orf24)
rab5 proto-oncogene protein
General
membrane protein
nuclear protein
phosphoprotein
Properties
SIZE: MW = 80 kD
entity length = 717 aa
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {2-164}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S12}
Ser phosphorylation site {S38}
Ser phosphorylation site {S54}
arginine-rich region {100-105}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S116}
transmembrane domain {213-233}
coiled coil {273-296}
glycine-rich region {316-322}
coiled coil {348-440}
glycine-rich region {468-471}
coiled coil {475-506}
Unc84 {601-717}
Database Correlations
UniProt Q9UH99
Pfam PF07738
References
UniProt :accession Q9UH99