R-spondin-4 (roof plate-specific spondin-4, hRspo4, RSPO4, C20orf182)

Function: 1) activator of the beta-catenin signaling cascade 2) TCF-dependent gene activation 3) role in Wnt/beta-catenin-dependent pathway - via a direct interaction with Wnt proteins 4) role in Wnt-independent beta catenin pathway 5) binds heparin 6) FU repeat required for activation & stabilization of beta-catenin 7) Tyr-112 may be phosphorylated, but is probably extracellular 8) upon injection into mice, induces rapid onset of crypt cell proliferation involving beta-catenin stabilization 9) efficacy in a model of chemotherapy-induced intestinal mucositis Compartment: secreted Alternative splicing: named isoforms=2

General

glycoprotein R-spondin (roof plate-specific spondin)

Properties

SIZE: MW = 26 kD entity length = 234 aa MOTIF: signal sequence {1-19} N-glycosylation site {N34} FU repeat {85-128} MOTIF: Tyr phosphorylation site {Y112} TSP TYPE-1 {138-197} MOTIF: cysteine residue {C139} MODIFICATION: cysteine residue {C181} cysteine residue {C150} MODIFICATION: cysteine residue {C157} cysteine residue {C157} MODIFICATION: cysteine residue {C150} cysteine residue {C181} MODIFICATION: cysteine residue {C139} cysteine residue {C190} MODIFICATION: cysteine residue {C196} cysteine residue {C196} MODIFICATION: cysteine residue {C190}

References

UniProt :accession Q2I0M5