R-spondin-2 (roof plate-specific spondin-2, hRspo2, RSPO2)

Function: 1) activator of the beta-catenin signaling cascade 2) TCF-dependent gene activation 3) role in Wnt/beta-catenin-dependent pathway - via a direct interaction with Wnt proteins 4) role in Wnt-independent beta catenin pathway 5) acts as a ligand for frizzled FZD8 & LRP6 6) interacts with WNT1 8) binds heparin 9) FU repeat required for activation & stabilization of beta-catenin 10) upon injection into mice, induces rapid onset of crypt cell proliferation involving beta-catenin stabilization 11) efficacy in a model of chemotherapy-induced intestinal mucositis Compartment: secreted Alternative splicing: named isoforms=3

General

glycoprotein R-spondin (roof plate-specific spondin)

Properties

SIZE: MW = 28 kD entity length = 243 aa MOTIF: signal sequence {1-21} FU repeat {90-134} TSP TYPE-1 {144-204} MOTIF: cysteine residue {C145} MODIFICATION: cysteine residue {C187} cysteine residue {C156} MODIFICATION: cysteine residue {C163} N-glycosylation site {N160} cysteine residue {C163} MODIFICATION: cysteine residue {C156} cysteine residue {C187} MODIFICATION: cysteine residue {C145} cysteine residue {C196} MODIFICATION: cysteine residue {C203} cysteine residue {C203} MODIFICATION: cysteine residue {C196}

References

UniProt :accession Q6UXX9