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R-spondin-1 (roof plate-specific spondin-1, hRspo1, RSPO1)
Function:
1) activator of the beta-catenin signaling cascade
2) TCF-dependent gene activation
3) role in Wnt/beta-catenin-dependent pathway
- via a direct interaction with Wnt proteins
4) role in Wnt-independent beta catenin pathway
5) acts as a ligand for frizzled FZD8 & LRP6
6) may negatively regulate the TGF-beta pathway
7) interacts with the extracelular domain of FZD8 & LRP6 (does NOT form a ternary complex)
8) interacts with WNT1
9) binds heparin
10) FU repeats required for activation & stabilization of beta-catenin
11) upon injection into mice, induces rapid onset of crypt cell proliferation involving beta-catenin stabilization
12) efficacy in a model of chemotherapy-induced intestinal mucositis
Compartment: secreted
Alternative splicing: named isoforms=2
General
glycoprotein
R-spondin (roof plate-specific spondin)
secreted protein
Properties
SIZE: MW = 29 kD
entity length = 263 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
FU repeat {34-85}
FU repeat {91-135}
N-glycosylation site {N137}
TSP TYPE-1 {147-207}
MOTIF: cysteine residue {C148}
MODIFICATION: cysteine residue {C190}
cysteine residue {C159}
MODIFICATION: cysteine residue {C166}
cysteine residue {C166}
MODIFICATION: cysteine residue {C159}
cysteine residue {C190}
MODIFICATION: cysteine residue {C148}
cysteine residue {C199}
MODIFICATION: cysteine residue {C206}
cysteine residue {C206}
MODIFICATION: cysteine residue {C199}
Database Correlations
UniProt Q2MKA7
Pfam PF00090
References
UniProt :accession Q2MKA7