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cadherin-4; retinal cadherin; R-cadherin; R-CAD (CDH4)
Function:
- cadherin
- role in retinal development (putative)
Structure: contains 5 cadherin domains
Compartment: cell membrane
Expression:
- expressed mainly in brain but also found in other tissues
General
cadherin
glycoprotein
Properties
SIZE: entity length = 916 aa
MW = 100 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-20}
cadherin domain {170-277}
cadherin domain {278-392}
MOTIF: N-glycosylation site {N283}
cadherin domain {393-507}
MOTIF: N-glycosylation site {N412}
cadherin domain {508-613}
MOTIF: N-glycosylation site {N557}
cadherin domain {614-724}
MOTIF: N-glycosylation site {N632}
N-glycosylation site {N661}
N-glycosylation site {N702}
transmembrane domain {735-756}
serine-rich region {873-888}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 603006
UniProt P55283
PFAM correlations
Entrez Gene 1002
Kegg hsa:1002
References
- UniProt :accession P55283
- Takeichi M.
Cadherin cell adhesion receptors as a morphogenetic regulator.
Science. 1991 Mar 22;251(5000):1451-5. Review.
PMID: 2006419
- Walsh FS et al
N-cadherin gene maps to human chromosome 18 and is not linked
to the E-cadherin gene.
J Neurochem. 1990 Sep;55(3):805-12.
PMID: 2384753