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tyrosine-protein kinase RYK (RYK, JTK5A)
Function:
- coreceptor along with Frizzled for Wnt ligands
- required for neurite outgrowth induced by Wnt-3a
- required in the activation of T cell factor (TCF) induced by Wnt-1
- binds dishevelled through which it activates canonical Wnt pathway
- interacts with frizzled 8
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family
- contains 1 protein kinase domain
- contains 1 WIF domain
Compartment: membrane (putative)
Alternative splicing: named isoforms=2
Expression: observed in all tissues examined
Interactions
molecular events
General
glycoprotein
tyrosine kinase receptor (RTK)
Properties
SIZE: entity length = 604 aa
MW = 68 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-25}
WIF {63-191}
MOTIF: N-glycosylation site {N136}
N-glycosylation site {N171}
N-glycosylation site {N175}
N-glycosylation site {N179}
N-glycosylation site {N206}
transmembrane domain {225-252}
kinase domain
SITE: 327-600
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 333-341
ATP-binding site
NAME: ATP-binding site
SITE: 361-361
aspartate residue {D462}
Tyr phosphorylation site {Y492}
Database Correlations
OMIM 600524
UniProt P34925
PFAM correlations
Entrez Gene 6259
Kegg hsa:6259
ENZYME 2.7.10.1
References
- Lu W et al
Mammalian Ryk is a Wnt coreceptor required for stimulation of
neurite outgrowth.
Cell 119:97-108, 2004
PMID: 15454084
- Entrez Gene :accession 8325