rRNA/tRNA 2'-O-methyltransferase fibrillarin-like (FBLL1)

Function: - role in pre-rRNA processing - utilizes methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA Structure: - belongs to the fibrillarin family - by homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA) Compartment: - nucleus, nucleolus - fibrillar region of the nucleolus (putative)

General

methyltransferase nuclear protein

Properties

SIZE: entity length = 333 aa MW = 35 kD COMPARTMENT: cell nucleus MOTIF: glycine-rich region {9-83} binding site SITE: 155-155 FOR-BINDING-OF: S-adenosylmethionine S-adenosyl-L-methionine binding {184-185} S-adenosyl-L-methionine binding {203-204} S-adenosyl-L-methionine binding {228-229} binding site SITE: 248-248 FOR-BINDING-OF: S-adenosylmethionine

Database Correlations

UniProt A6NHQ2 Pfam PF01269

References

UniProt :accession A6NHQ2