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RPE-retinal G protein-coupled receptor (RGR)
Function:
- receptor for all-trans-retinal & 11-cis-retinal
- preferentially binds all-trans-retinal
- may catalyze the isomerization of the retinal by a retinochrome-like mechanism
- covalently binds all-trans-retinal & 11-cis-retinal
Structure:
- belongs to the G-protein coupled receptor 1 family Opsin subfamily
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- preferentially expressed at high levels in the retinal pigment epithelium (RPE) & Mueller cells of the neural retina
Pathology:
- defects in RGR are a cause of retinitis pigmentosa
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 291 aa
MW = 32 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-15}
transmembrane domain {16-36}
cytoplasmic loop {37-52}
transmembrane domain {53-73}
exoplasmic loop {74-91}
MOTIF: cysteine residue {C88}
MODIFICATION: cysteine residue {C162}
transmembrane domain {92-112}
cytoplasmic loop {113-130}
transmembrane domain {131-151}
exoplasmic loop {152-175}
MOTIF: cysteine residue {C162}
MODIFICATION: cysteine residue {C88}
N-glycosylation site {N172}
transmembrane domain {176-196}
cytoplasmic loop {197-219}
transmembrane domain {220-240}
exoplasmic loop {241-247}
transmembrane domain {248-268}
cytoplasmic domain {269-291}
Database Correlations
OMIM correlations
MORBIDMAP 600342
UniProt P47804
Pfam PF00001
Entrez Gene 5995
Kegg hsa:5995
References
- UniProt :accession P47804
- Mutations of the RGR gene;
Retina International's scientific newsletter
http://www.retina-international.com/sci-news/rgrmut.htm
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/RGR