RPA-interacting protein (hRIP) (RPAIN RIP)

Function: - mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta - isoform 2 is sumoylated & mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism - interacts with the RPA1 subunit of RPA complex - sumoylation is required for localization in nuclear PML body & transport of RPA complex in PML body - upon UV irradiation & during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage - sumoylation takes place at different Lys residues Structure: contains 1 RIP-type zinc finger Compartment: - isoform 1: cytoplasm, nucleus - isoform 2: nucleus, only nuclear, localizes to PML body Alternative splicing: named isoforms=7 Expression: - widely expressed - expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus & spleen

General

nuclear protein zinc finger protein

Properties

SIZE: MW = 25 kD entity length = 219 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: Zinc finger NAME: Zinc finger SITE: 137-212 EFFECTOR-BOUND: Zn+2 MOTIF: Mediates nuclear export {164-180}

References

UniProt :accession Q86UA6