roundabout homolog 3 (roundabout-like protein 3, ROBO3)

Function: 1) role in neural development - role in axonal navigation at ventral midline of the neural tub 2) role in spinal cord development - role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (putative) 3) required for hindbrain axon midline crossing 4) probably interacts with SLIT2 Structure: 1) belongs to the immunoglobulin superfamily, ROBO family 2) contains 3 fibronectin F3 modules - contains 5 Ig-like C2-type domains (immunoglobulin-like) Compartment: membrane Alternative splicing: named isoforms=2 Pathology: - defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis

General

glycoprotein immunoglobulin superfamily protein membrane protein

Properties

SIZE: MW = 148 kD entity length = 1386 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-20} N-glycosylation site {N25} N-glycosylation site {N34} N-glycosylation site {N41} N-glycosylation site {N53} immunoglobulin superfamily domain {64-160} MOTIF: cysteine residue {C85} MODIFICATION: cysteine residue {C143} cysteine residue {C143} MODIFICATION: cysteine residue {C85} N-glycosylation site {N156} immunoglobulin superfamily domain {166-253} MOTIF: cysteine residue {C187} MODIFICATION: cysteine residue {C236} cysteine residue {C236} MODIFICATION: cysteine residue {C187} immunoglobulin superfamily domain {258-342} MOTIF: cysteine residue {C279} MODIFICATION: cysteine residue {C326} cysteine residue {C326} MODIFICATION: cysteine residue {C279} immunoglobulin superfamily domain {347-440} MOTIF: cysteine residue {C368} MODIFICATION: cysteine residue {C424} N-glycosylation site {N410} cysteine residue {C424} MODIFICATION: cysteine residue {C368} immunoglobulin superfamily domain {450-531} MOTIF: N-glycosylation site {N459} cysteine residue {C472} MODIFICATION: cysteine residue {C521} N-glycosylation site {N503} cysteine residue {C521} MODIFICATION: cysteine residue {C472} fibronectin type III domain or F3 module {555-647} fibronectin type III domain or F3 module {669-762} fibronectin type III domain or F3 module {768-863} MOTIF: N-glycosylation site {N784} N-glycosylation site {N813} N-glycosylation site {N820} transmembrane domain {892-912}

Database Correlations

OMIM correlations MORBIDMAP 608630 UniProt Q96MS0 PFAM correlations