roundabout homolog 2 (ROBO2, KIAA1568, SAX3)

Function: - receptor for SLIT2 & probably SLIT1 - molecular guidance in cellular migration, including axonal navigation at ventral midline of neural tube & projection of axons to different regions during neuronal development Compartment: membrane Alternative splicing: named isoforms=2 Structure: - belongs to the immunoglobulin superfamily, ROBO family - contains 3 fibronectin F3 modules - contains 5 Ig-like C2-type domains (immunoglobulin-like)

General

cell surface receptor glycoprotein immunoglobulin superfamily protein

Properties

SIZE: MW = 151 kD entity length = 1378 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-21} immunoglobulin superfamily domain {31-127} MOTIF: cysteine residue {C52} MODIFICATION: cysteine residue {C110} cysteine residue {C110} MODIFICATION: cysteine residue {C52} N-glycosylation site {N123} immunoglobulin superfamily domain {133-220} MOTIF: cysteine residue {C154} MODIFICATION: cysteine residue {C203} cysteine residue {C203} MODIFICATION: cysteine residue {C154} immunoglobulin superfamily domain {225-309} MOTIF: cysteine residue {C246} MODIFICATION: cysteine residue {C293} cysteine residue {C293} MODIFICATION: cysteine residue {C246} immunoglobulin superfamily domain {314-409} MOTIF: cysteine residue {C335} MODIFICATION: cysteine residue {C391} cysteine residue {C391} MODIFICATION: cysteine residue {C335} immunoglobulin superfamily domain {418-504} MOTIF: N-glycosylation site {N426} cysteine residue {C439} MODIFICATION: cysteine residue {C488} cysteine residue {C488} MODIFICATION: cysteine residue {C439} fibronectin type III domain or F3 module {522-607} fibronectin type III domain or F3 module {634-724} fibronectin type III domain or F3 module {736-826} MOTIF: N-glycosylation site {N752} N-glycosylation site {N782} N-glycosylation site {N789} N-glycosylation site {N845} transmembrane domain {860-880}

Database Correlations

OMIM 602431 UniProt Q9HCK4 PFAM correlations

References

UniProt :accession Q9HCK4