rootletin (ciliary rootlet coiled-coil protein, CROCC. KIAA0445)

Function: - major structural component of the ciliary rootlet - contributes to centrosome cohesion before mitosis - interacts with KLC3, NEK2 & the N-terminus of CEP250 - phosphorylated by NEK2 which may regulate its association with centrosomes - hosphorylated upon DNA damage, probably by ATM or ATR Structure: - homopolymer - belongs to the rootletin family Compartment: - centrosome, centriole - In ciliated cells, associated with ciliary rootlets - in non-ciliated cells, localized between, around & at the proximal ends of the centrioles - dissociates from the centrioles at the onset of mitosis & reassociates with them at anaphase Alternative splicing: named isoforms=2

General

cytoskeletal protein phosphoprotein

Properties

SIZE: MW = 229 kD entity length = 2017 aa COMPARTMENT: cytoplasm MOTIF: coiled coil {70-262} coiled coil {318-444} coiled coil {546-1058} coiled coil {1091-1438} coiled coil {1505-1704} MOTIF: Ser phosphorylation site {S1619} glutamine-rich region {1921-1999} MOTIF: glutamine residue (SEVERAL)

References

UniProt :accession Q5TZA2