role of APP in axonal transport

The amyloid precursor protein (APP) may function as a kinesin-1 membrane receptor, mediated by binding of APP to the kinesin light chain subunit of kinesin-1. The APP-kinesin-1 interaction facilites fast anterograde axonal transport of a compartment containing several proteins. These include: 1) APP beta-secretase 2) presenilin-1 3) GAP-43 4) synapsin-1 5) tyrosine kinase receptor A NOT included (transported by different mechanisms): 1) synaptotagmin 2) synaptophysin

References

- Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001 Dec 6;414(6864):643-8. PMID: 11740561