BRE1A/BRE1B/UBE2E1 (RNF20/40) complex

Ubiquitin ligase complex

General

molecular complex nuclear protein

Properties

COMPARTMENT: cell nucleus SUBUNITS: E3 ubiquitin-protein ligase BRE1A (2) COMPARTMENT: cell nucleus MOTIF: coiled coil {43-90} Ser phosphorylation site {S136} Ser phosphorylation site {S138} coiled coil {168-375} MOTIF: Tyr phosphorylation site {Y314} coiled coil {429-898} MOTIF: Ser phosphorylation site {S540} Ser phosphorylation site {S545} Ser phosphorylation site {S553} RING-finger {922-961} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif E3 ubiquitin-protein ligase BRE1B (2) COMPARTMENT: cell nucleus MOTIF: coiled coil {44-91} coiled coil {189-377} coiled coil {437-525} coiled coil {627-946} MOTIF: Thr phosphorylation site {T644} RING-finger {948-987} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif ubiquitin-conjugating enzyme E2 E1 COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S2} serine-rich region {9-18} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S9} Ser phosphorylation site {S12} Tyr phosphorylation site {Y77} cysteine residue {C131}

References

UniProt :accession O75150

Components

E3 ubiquitin-protein ligase BRE1A; BRE1-A; hBRE1; RING finger protein 20 (RNF20, BRE1A) E3 ubiquitin-protein ligase BRE1B; BRE1-B; 95 kD retinoblastoma-associated protein; RBP95; RING finger protein 40 (RNF40, BRE1B, KIAA0661) ubiquitin-conjugating enzyme E2 E1; UbcH6; ubiquitin carrier protein E1; ubiquitin-protein ligase E1 (UBE2E1, UBCH6)