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RNA vaccine
Indications:
- treatment of cutaneous melanoma, including late-stage melanoma [1]
Advantages:
- can be produced rapidly
- elicit both antibody & T-cell responses
Procedure:
- typically enclosed in lipid nanocapsules
- injected & taken up by host dendritic cells
- the dendritic cells produce mRNA-encoded peptides (immunogens) in conjunction with major histocompatibility complex I proteins to elicit T-cell response
General
vaccine
References
- Sahin U et al.
An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma.
Nature 2020 Sep; 585:107.
PMID: 32728218
https://www.nature.com/articles/s41586-020-2537-9