RNA polymerase 2 transcription factor SIII subunit A3-like-1 (elongin-A3-like-1, eloA3-like-1, transcription elongation factor B polypeptide 3C-like-1, TCEB3CL)

Function: - SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase 2 transcription elongation past template-encoded arresting sites - subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B & C (elongin BC complex) - heterotrimer of an A (A1, A2 or A3), B & C subunit Structure: - elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] - contains 1 TFIIS N-terminal domain Compartment: nucleus (putative)

Properties

SIZE: entity length = 546 aa MW = 60 kD COMPARTMENT: cell nucleus MOTIF: TFIIS N-terminal {5-80} proline-rich region SITE: 119-193 MOTIF: proline residue (SEVERAL) Activation domain {308-467} MOTIF: BC complex binding domain {336-345}

Database Correlations

PFAM correlations Kegg hsa:7289

References

UniProt :accession Q3SY89 (deprecated)