DNA-directed RNA polymerase III subunit RPC5; RNA polymerase III subunit C5; DNA-directed RNA polymerase III 80 kD polypeptide (POLR3E, KIAA1452)

Function: - specific peripheral component of RNA polymerase 3 - essential for efficient transcription from both the type 2 VAI & type 3 U6 RNA polymerase 3 promoters - role in sensing & limiting infection by intracellular bacteria & DNA viruses - acts as nuclear & cytosolic DNA sensor involved in innate immune response - can sense non-self dsDNA that serves as template for transcription into dsRNA - the non-self RNA polymerase 3 transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type 1 interferon & NF- Kappa-B through the RIG-I pathway - interacts with POLR3D/RPC4 Compartment: nucleus Alternative splicing: named isoforms=3

General

nuclear protein phosphoprotein protein subunit

Properties

SIZE: entity length = 708 aa MW = 80 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S161} Ser phosphorylation site {S162} Tyr phosphorylation site {Y224} Ser phosphorylation site {S503} Ser phosphorylation site {S522}

Database Correlations

UniProt Q9NVU0 Pfam PF04801 Entrez Gene 55718 Kegg hsa:55718

References

UniProt :accession Q9NVU0