DNA-directed RNA polymerase III subunit RPC2; RNA polymerase III subunit C2; C128; DNA-directed RNA polymerase III 127.6 kD polypeptide; DNA-directed RNA polymerase III subunit B (POLR3B)

Function: - second largest core component of RNA polymerase 3 - contributes to the polymerase catalytic activity & forms the polymerase active center together with the largest subunit of polymerase 3 - part of the core element of RNA polymerase 3 with the central large cleft & probably a clamp element that moves to open & close the cleft (putative) - role in sensing & limiting infection by intracellular bacteria & DNA viruses - acts as nuclear & cytosolic DNA sensor involved in innate immune response - can sense non-self dsDNA that serves as template for transcription into dsRNA - the non-self RNA polymerase 3 transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type 1 interferon & NF- Kappa-B through the RIG-I pathway Structure: belongs to the RNA polymerase beta chain family Compartment: nucleus (putative)

General

nuclear protein phosphoprotein protein subunit zinc finger protein

Properties

SIZE: entity length = 1133 aa MW = 128 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S202} Ser phosphorylation site {S206} Zn finger C4-type SITE: 1080-1095 EFFECTOR-BOUND: Zn+2 MOTIF: Zn+2-binding site SITE: 1080-1080 Zn+2-binding site SITE: 1083-1083 Zn+2-binding site SITE: 1092-1092 Zn+2-binding site SITE: 1095-1095

Database Correlations

UniProt Q9NW08 PFAM correlations Entrez Gene 55703 ENZYME 2.7.7.6

References

UniProt :accession Q9NW08