DNA-directed RNA polymerase III subunit RPC3; RNA polymerase III subunit C3; DNA-directed RNA polymerase III subunit C; RNA polymerase III 62 kD subunit; RPC62 (POLR3C)

Function: - specific core component of RNA polymerase 3 - may direct with other members of the subcomplex RNA polymerase 3 binding to the TFIIIB-DNA complex via interactions between TFIIIB & POLR3F - may be involved either in the recruitment & stabilization of the subcomplex within RNA polymerase 3, or in stimulating catalytic functions of other subunits during initiation - plays a key role in sensing & limiting infection by intracellular bacteria & DNA viruses - acts as nuclear & cytosolic DNA sensor involved in innate immune response - can sense non-self dsDNA that serves as template for transcription into dsRNA - the non-self RNA polymerase 3 transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type 1 interferon & NF- Kappa-B through the RIG-I pathway - interacts with GTF3C4 (putative) Structure: - belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family Compartment: nucleus (putative) Pathology: - autoantibodies against POLR3C have been found in the sera of patients with systemic sclerosis (SSc)

General

nuclear protein phosphoprotein protein subunit

Properties

SIZE: entity length = 534 aa MW = 61 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S194}

Database Correlations

UniProt Q9BUI4 PFAM correlations Entrez Gene 10623 Kegg hsa:10623

References

UniProt :accession Q9BUI4