DNA-directed RNA polymerase III subunit RPC6; RNA polymerase III subunit C6; DNA-directed RNA polymerase III subunit F; RNA polymerase III 39 kD subunit; RPC39 (POLR3F)

Function: - specific peripheral component of RNA polymerase 3 - role in sensing & limiting infection by intracellular bacteria & DNA viruses - acts as nuclear & cytosolic DNA sensor involved in innate immune response - can sense non-self dsDNA that serves as template for transcription into dsRNA - the non-self RNA polymerase 3 transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type 1 interferon & NF- Kappa-B through the RIG-I pathway - RPC3/POLR3C, RPC6/POLR3F & RPC7/POLR3G form an RNA polymerase 3 subcomplex (putative) - interacts with TBP & TFIIIB90 & GTF3C4 Structure: - belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family Compartment: nucleus (putative)

General

nuclear protein protein subunit

Properties

SIZE: entity length = 316 aa MW = 36 kD COMPARTMENT: cell nucleus

Database Correlations

UniProt Q9H1D9 Pfam PF05158 Entrez Gene 10621 Kegg hsa:10621

References

UniProt :accession Q9H1D9