DNA-directed RNA polymerase III subunit RPC8; RNA polymerase III subunit C8; DNA-directed RNA polymerase III subunit H; RNA polymerase III 22.9 kD subunit; RPC22.9 (POLR3H, KIAA1665, RPC8)

Function: - specific peripheral component of RNA polymerase 3 - role in sensing & limiting infection by intracellular bacteria & DNA viruses - acts as nuclear & cytosolic DNA sensor involved in innate immune response. can sense non-self dsDNA that serves as template for transcription into dsRNA - the non-self RNA polymerase 3 transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type 1 interferon & NF- Kappa-B through the RIG-I pathway (putative) - interacts with CRCP/RPC9 - POLR3H/RPC8 & CRCP/RPC9 probably form an RNA polymerase 3 subcomplex Structure: - belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family Compartment: nucleus Alternative splicing: named isoforms=2

General

nuclear protein protein subunit

Properties

SIZE: entity length = 204 aa MW = 23 kD COMPARTMENT: cell nucleus

Database Correlations

UniProt Q9Y535 PFAM correlations Entrez Gene 171568 Kegg hsa:171568

References

UniProt :accession Q9Y535