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unconventional prefoldin RPB5 interactor; protein NNX3; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein (RMP, URI1, C19orf2. NNX3 .URI)
Function:
- seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs & proteins with roles in transcription & ubiquitination
- component of the URI complex that contains PFDN2, POLR2E/RPB5, RUVBL2, RUVBL1 & RMP. interacts with POLR2E/RPB5
Structure:
- belongs to the RNA polymerase II subunit 5-mediating protein family
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression: ubiquitous
Related
RNA polymerases 1, 2, & 3 subunit RPABC1 (RNA polymerases 1, 2, & 3 subunit ABC1, RNA polymerase 2 23 kD subunit, RNA polymerase 2 subunit E, RNA polymerase 2 subunit 5, POLR2E, RPABC1, RPB25, RBP5, XAP4)
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 535 aa
MW = 60 kD
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T241}
Thr phosphorylation site {T242}
Ser phosphorylation site {S243}
Ser phosphorylation site {S244}
Ser phosphorylation site {S440}
Database Correlations
OMIM 603494
UniProt O94763
Pfam PF02996
Entrez Gene 8725
Kegg hsa:8725
References
UniProt :accession O94763