Search
RNA polymerase 2 p16 kD subunit (RPB4, RNA polymerase 2 subunit D, POLR2D)
Function:
- component of the RNA polymerase 2 complex
- POLR2D is part of a subcomplex with POLR2G that binds to a pocket formed by POLR2A, POLR2B & POLR2F at the base of the clamp element. The POLR2D-POLR2G subcomplex seems to lock the clamp via POLR2D in the closed conformation thus preventing double stranded DNA to enter the active site cleft
- the POLR2D-POLR2G subcomplex
a) protrudes from the RNA polymerase 2 core complex
b) binds single-stranded DNA & RNA
Structure:
- belongs to the eukaryotic RPB4 RNA polymerase subunit family
Compartment: nucleus (putative)
General
nuclear protein
rna polymerase subunit
Properties
Database Correlations
OMIM 606017
UniProt O15514
Pfam PF03874
Kegg hsa:5433
References
UniProt :accession O15514
Component-of
RNA polymerase-2