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RNA polymerase II elongation factor ELL; eleven-nineteen lysine-rich leukemia protein (ELL, C19orf17)
Function:
- transcription elongation factor
- can increase the catalytic rate of RNA polymerase 2 transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with EAF1 & EAF2
Structure: belongs to the ELL/occludin family
Compartment:
- nuclear speckle, nucleus, Cajal body
- colocalizes with EAF2 to nuclear speckles
- also localized to Cajal (coiled) bodies
Expression:
- expressed in all tissues tested
- highest levels found in placenta, skeletal muscle, testis & peripheral blood leukocytes
Pathology:
- chromosomal translocation t(11;19)(q23;p13.1) involving ELL with MLL/HRX is found in acute leukemias
- the result is a rogue activator protein
Related
RNA polymerase-2
General
nuclear protein
phosphoprotein
proto oncogene protein
Properties
SIZE: entity length = 621 aa
MW = 68 kD
COMPARTMENT: cell nucleus
MOTIF: aspartate residue {46}
Thr phosphorylation site {T170}
Ser phosphorylation site {S309}
nuclear translocation signal {445-459}
Ser phosphorylation site {S561}
Database Correlations
OMIM 600284
UniProt P55199
PFAM correlations
Entrez Gene 8178
Kegg hsa:8178
References
- UniProt :accession P55199
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/ELL.html