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RNA polymerase-2 CTD consensus repeat

Function: - the largest subunit of eukaryotic RNA polymerase 2 contains an unsusual C-terminal domain comprising multiple repeats of the consensus sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser - 52 in mice [2] or mammals [3] - 42 in Drosophila - 26 in yeast - unphosphorylated CTD consensus repeat serves as binding site for TFIID anchoring RNA polymerase 2 complex at start site - phosphorylation by TFIIH K subunit releases attachment to TFIID - c-abl phosphorylates CTD on Tyr

Related

RNA polymerase 2 largest subunit; RPB1; RNA polymerase 2 subunit A; RNA polymerase 2 subunit B1 (POLR2A) RNA polymerase-2

General

binding site peptide motif consensus repeat

Properties

NAME: RNA polymerase-2 CTD consensus repeat QUANTITY: 52 SITE: C-TERMINAL MOTIF: Ser phosphorylation site (3) Thr phosphorylation site Tyr phosphorylation site MISC-INFO: consensus

References

  1. UI89295557
  2. Drapkin R, Reinberg D. Transcription. The essential twist. Nature. 1994 Jun 16;369(6481):523-4. No abstract available. PMID: 8202151
  3. Drapkin R, Reinberg D. The multifunctional TFIIH complex and transcriptional control. Trends Biochem Sci. 1994 Nov;19(11):504-8. Review. PMID: 7855896