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trimethylguanosine synthase; CLL-associated antigen KW-2; Cap-specific guanine-N2 methyltransferase; hepatocellular carcinoma-associated antigen 137; nuclear receptor coactivator 6-interacting protein; PRIP-interacting protein with methyltransferase motif; PIMT; PIPMT (TGS1, HCA137, NCOA6IP, PIMT)
Function:
1) methyltransferase (putative)
2) binds S-adenosyl-L-methionine & RNA
3) transcriptional regulation
4) interacts with NCOA6, CREBBP, EP300, PPARBP, SMN
Kinetic parameters:
- KM=30 uM for m(7)GDP
- KM=5 uM for S-adenosyl-L-methionine
- pH dependence: optimum pH is 8.5-9.5
Structure: may form homooligomers
Compartment: nucleus
Expression:
- ubiquitously expressed
- high expression in heart, skeletal muscle, kidney, liver, placenta
General
methyltransferase
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 853 aa
MW = 97 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S55}
Thr phosphorylation site {T60}
Ser phosphorylation site {S85}
Ser phosphorylation site {S89}
Ser phosphorylation site {S154}
Ser phosphorylation site {S298}
Ser phosphorylation site {S405}
Thr phosphorylation site {T407}
Ser phosphorylation site {S412}
Ser phosphorylation site {S438}
lysine-rich region {611-624}
MOTIF: lysine residue (SEVERAL)
active site
SITE: 631-846
MOTIF: binding site
SITE: 719-719
FOR-BINDING-OF: S-adenosylmethionine
binding site
SITE: 766-766
FOR-BINDING-OF: 7-methylguanosine
Database Correlations
OMIM 606461
UniProt Q96RS0
Pfam PF09445
Entrez Gene 96764
Kegg hsa:96764
References
UniProt :accession Q96RS0