RNA-binding protein 40 (RNA-binding motif protein 40, RNA-binding region-containing protein 3, U11/U12 small nuclear ribonucleoprotein 65 kD protein, U11/U12 snRNP 65 kD protein, U11/U12-65K, RNPC3, KIAA1839, RBM40, RNP)

Function: - RNA-binding protein - role in pre-mRNA splicing - participates in pre-mRNA U12-dependent splicing - binds to the 3'-stem-loop of m(7)G-capped U12 snRNA - component of the U11/U12 snRNPs that are part of the U12-type spliceosome - found in a complex with m(7)G-capped U12 snRNA - interacts with PDCD7 Structure: contains 2 RRM (RNA recognition motif) domains Compartment: nucleus Expression: - highly expressed in pancreas & kidney - detected at lower levels in heart, brain, placenta, lung, liver, spleen, thymus, prostate, testis, ovary, small intestine, colon & leukocytes

General

nuclear protein RNA-binding protein

Properties

SIZE: entity length = 517 aa MW = 59 kD COMPARTMENT: cell nucleus MOTIF: PDCD7 interaction {1-257} MOTIF: RNP motif NAME: RNP motif SITE: 27-102 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S108} proline-rich region SITE: 196-233 MOTIF: proline residue (SEVERAL) m(7)G-capped U12 snRNA interaction {211-380} RNP motif NAME: RNP motif SITE: 420-503 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif

Database Correlations

UniProt Q96LT9 Pfam PF00076

References

UniProt :accession Q96LT9