RNA-binding motif protein, Y chromosome, family 1 member D (RBMY1D)

Function: - RNA-binding protein - may be involved in spermatogenesis - required for sperm development, possibly by participating in pre-mRNA splicing in the testis - interacts with splicing factor proteins SFRS3/SRP20, SFRS10, KHDRBS1/SAM68 & KHDRBS3 Structure: contains 1 RRM domain (RNA recognition motif) Compartment: nucleus Expression: - testis-specific - expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids Genetics: - the RBMY1 proteins are encoded by strongly repeated regions of the Y chromosome, mostly within the AZFb region - the exact number of functional copies is unclear & may vary between individuals, & some of them may represent pseudogenes - the proteins are very similar, which makes their indidual characterization difficult - thus, most experiments do not discriminate between the different members - reported interactions with a RBMY1 protein likely involve all the proteins

General

nuclear protein RNA-binding protein testis-specific protein

Properties

SIZE: entity length = 496 aa MW = 56 kD COMPARTMENT: cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 8-85 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif arginine-rich region {254-340} MOTIF: arginine residue (SEVERAL)

References

UniProt :accession P0C7P1