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RNA-binding protein 9; RNA-binding motif protein 9; Fox-1 homolog B; hexaribonucleotide-binding protein 2; repressor of tamoxifen transcriptional activity (RBM9, FOX2, RBFOX2, HRNBP2, RTA)
Function:
- RNA-binding protein
- regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements
- prevents binding of U2AF2 to the 3'-splice site
- regulates alternative splicing of tissue-specific exons & of differentially spliced exons during erythropoiesis (putative)
- seems to act as a coregulatory factor of ER-alpha
- interacts with ER-alpha N-terminal activation domain
Structure:
- contains 1 RRM domain (RNA recognition motif)
Compartment:
- nucleus, cytoplasm (putative)
Alternative splicing: named isoforms=10
General
nuclear protein
RNA-binding motif protein
Properties
SIZE: entity length = 390 aa
MW = 41 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: RNP motif
NAME: RNP motif
SITE: 121-197
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
arginine residue {122}
phenylalanine residue {130}
arginine residue {131}
asparagine residue {155}
lysine residue {160}
phenylalanine residue {164}
arginine residue {188}
arginine residue {198}
alanine-rich region {273-377}
MOTIF: alanine residue (SEVERAL)
Database Correlations
UniProt O43251
Pfam PF00076
Entrez Gene 23543
Kegg hsa:23543
References
UniProt :accession O43251