RNA-binding protein 8A; RNA-binding motif protein 8A; ribonucleoprotein RBM8A; RNA-binding protein Y14; binder of OVCA1-1; BOV-1 (RBM8A, RBM8, HSPC114, MDS014)

Function: - component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs - heterodimer with MAGOH a) component of the nonsense mediated decay (NMD) pathway b) interacts with PYM to enhance translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex - found in a post-splicing complex with NXF1, RBM8A, RENT1, RENT2, RENT3A, RENT3B & RNPS1 - interacts with BAT1, MAGOH, OVCA1, RENT3B, RNPS1, SRRM1 & THOC4 - identified in the spliceosome C complex - interacts with WIBG/PYM; the interaction is direct - leads to dissociate the EJC from spliced mRNAs - associates with polysomes Structure: - belongs to the RBM8A family - contains 1 RRM domain (RNA recognition motif) Compartment: - nucleus, nuclear speckle, cytoplasm - nucleocytoplasmic shuttling protein - travels to the cytoplasm as part of the exon junction complex bound to mRNA - colocalizes with the core exon junction complex, THOC4, NXF1 & UAP56 in the nucleus & nuclear speckles Alternative splicing: named isoforms=2 Expression: ubiquitous

General

nuclear protein phosphoprotein RNA-binding motif protein

Properties

SIZE: entity length = 174 aa MW = 20 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S42} Ser phosphorylation site {S46} Ser phosphorylation site {S56} RNP motif NAME: RNP motif SITE: 73-151 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S166} Ser phosphorylation site {S168}

Database Correlations

OMIM 605313 UniProt Q9Y5S9 Pfam PF00076 Entrez Gene 9939 Kegg hsa:9939

References

UniProt :accession Q9Y5S9