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RNA-binding protein 6; RNA-binding motif protein 6; RNA-binding protein DEF-3; lung cancer antigen NY-LU-12; protein G16 (RBM6, DEF3)
Function:
- specifically binds poly(G) RNA homopolymers in vitro
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- contains 1 G-patch domain
- contains 1 RRM domain (RNA recognition motif)
Compartment: nucleus (probable)
Expression: ubiquitous in adults
General
nuclear protein
phosphoprotein
RNA-binding motif protein
Properties
SIZE: entity length = 1123 aa
MW = 129 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S360}
Ser phosphorylation site {S362}
RNP motif
NAME: RNP motif
SITE: 456-536
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
glutamate-rich region {826-829}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S891}
proline-rich region
SITE: 892-895
MOTIF: proline residue (SEVERAL)
Tyr phosphorylation site {Y914}
glutamate-rich region {915-921}
MOTIF: glutamate residue (SEVERAL)
Thr phosphorylation site {T923}
Ser phosphorylation site {S1022}
Ser phosphorylation site {S1025}
G-patch domain {1051-1097}
Database Correlations
OMIM 606886
UniProt P78332
Pfam PF01585
Entrez Gene 10180
References
UniProt :accession P78332