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RNA-binding protein 15; RNA-binding motif protein 15; one-twenty two protein 1 (RBM15, OTT OTT1)

Function: - may be implicated in HOX gene regulation - phosphorylated upon DNA damage, probably by ATM or ATR - interacts with Epstein-Barr virus BSFL2/BMLF1 Structure: - belongs to the RRM spen family - contains 3 RRM domains (RNA recognition motif) - contains 1 SPOC domain Compartment: nucleus Alternative splicing: named isoforms=3 Pathology: - chromosomal translocation t(1;22)(p13;q13) involving RBM15 with MKL1 may be a cause of acute megakaryoblastic leukemia - although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene & is the candidate oncogene

General

nuclear protein phosphoprotein RNA-binding motif protein

Properties

SIZE: entity length = 977 aa MW = 107 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S51} serine-rich region {60-166} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S83} Ser phosphorylation site {S125} Ser phosphorylation site {S128} Ser phosphorylation site {S154} RNP motif NAME: RNP motif SITE: 170-252 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S179} Ser phosphorylation site {S257} Ser phosphorylation site {S259} Ser phosphorylation site {S292} Ser phosphorylation site {S294} Ser phosphorylation site {S365} RNP motif NAME: RNP motif SITE: 374-451 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 455-529 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Thr phosphorylation site {T568} arginine-rich region {616-732} MOTIF: arginine residue (SEVERAL) Ser phosphorylation site {S622} Ser phosphorylation site {S656} Ser phosphorylation site {S659} Ser phosphorylation site {S670} Ser phosphorylation site {S674} Ser phosphorylation site {S700} Ser phosphorylation site {S708} Ser phosphorylation site {S724} Ser phosphorylation site {S741} SPOC {777-956} MOTIF: Ser phosphorylation site {S781} Ser phosphorylation site {S935} breakpoint {954-955}

Database Correlations

OMIM 606077 UniProt Q96T37 PFAM correlations Entrez Gene 64783 Kegg hsa:64783

References

  1. UniProt :accession Q96T37
  2. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/OTTID175.html