RNA-binding protein 10; RNA-binding motif protein 10; G patch domain-containing protein 9; RNA-binding protein S1-1; S1-1 (RBM10, DXS8237E, GPATC9, GPATCH9, KIAA0122)

Function: - may be involved in post-transcriptional processing, most probably in mRNA splicing - binds to RNA homopolymers, with a preference for poly(G) & poly(U) & little for poly(A) - phosphorylated upon DNA damage, probably by ATM or ATR - associates with the spliceosome - component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 & KIF11/TRIP5 Structure: - contains 1 C2H2-type Zn⁺² finger - contains 1 G-patch domain - contains 1 RanBP2-type Zn⁺² finger - contains 2 RRM domain (RNA recognition motif)s Compartment: - nucleus - in the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner - upon globally reducing RNA polymerase 2 transcription, the nuclear bodies enlarge & decrease in number - they occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains) Alternative splicing: named isoforms=4

General

C2H2 type zinc finger protein nuclear protein phosphoprotein RNA-binding motif protein

Properties

SIZE: entity length = 930 aa MW = 104 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S50} Ser phosphorylation site {S60} Ser phosphorylation site {S61} Ser phosphorylation site {S65} arginine-rich region {80-87} MOTIF: arginine residue (SEVERAL) Ser phosphorylation site {S89} Thr phosphorylation site {T91} glutamate-rich region {113-125} MOTIF: glutamate residue (SEVERAL) RNP motif NAME: RNP motif SITE: 129-209 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Zinc finger NAME: Zinc finger SITE: 212-242 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S288} RNP motif NAME: RNP motif SITE: 300-384 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S723} Ser phosphorylation site {S733} Ser phosphorylation site {S736} Ser phosphorylation site {S738} Zn finger C2H2-type SITE: 759-784 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S797} G-patch domain {858-904}

Database Correlations

OMIM 300080 UniProt P98175 PFAM correlations Entrez Gene 8241 Kegg hsa:8241

References

UniProt :accession P98175