RNA 3'-terminal phosphate cyclase; RNA cyclase; RNA-3'-phosphate cyclase; RNA terminal phosphate cyclase domain-containing protein 1; RTC domain-containing protein 1 (RTCD1, RTC1, RTCA)

Function: - catalyzes conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA - the mechanism of action of the enzyme occurs in 3 steps: a) adenylation of the enzyme by ATP b) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A c) attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product - the biological role unknown - likely to function in some aspects of cellular RNA processing ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate Structure: - monomer - belongs to the RNA 3'-terminal cyclase family, type 1 subfamily Compartment: nucleus, nucleoplasm Alternative splicing: named isoforms=2 Expression: ubiquitous

General

adenosine triphosphatase (ATPase) nuclear protein

Properties

SIZE: entity length = 366 aa MW = 39 kD COMPARTMENT: cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 104-104 ATP-binding site NAME: ATP-binding site SITE: 294-298 histidine residue {H320}

Database Correlations

OMIM 611286 UniProt O00442 PFAM correlations Entrez Gene 8634 Kegg hsa:8634 ENZYME 6.5.1.4

References

UniProt :accession O00442