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RMI complex
Function:
- role in processing of homologous recombination intermediates to limit DNA crossover formation in cells
- the RMI complex interacts with BLM
Structure:
- subunits include TOP3A, RMI1 & RMI2
General
molecular complex
Properties
SUBUNITS: DNA topoisomerase 3-alpha
COMPARTMENT: cell nucleus
MOTIF: Toprim {35-179}
MOTIF: Ser phosphorylation site {S54}
tyrosine residue {Y362}
Zn finger C4-type
SITE: 658-685
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S771}
2 X 27 AA approximate repeats {812-923}
MOTIF: consensus repeat {812-839}
consensus repeat {896-923}
protein RMI1 homolog
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S292}
OB DNA-binding domain-containing protein C16orf175
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 44-114
References
UniProt :accession Q13472
Components
DNA topoisomerase 3-alpha; DNA topoisomerase III alpha (TOP3A, TOP3)
OB DNA-binding domain-containing protein C16orf175 (RMI2)
protein RMI1 homolog (75 kD BLM-associated protein, BLAP75, FAAP75, RMI1, C9orf76)