RING finger protein 43 (RNF43)

Structure: contains 1 RING-type zinc finger Compartment: membrane, secreted Expression: expressed in fetal kidney, fetal lung Pathology: - expressed in hepatocellular carcinomas, lung adenocarcinomas - overexpressed in colorectal cancer cell lines - acts as a cytotoxic T lymphocyte tumor antigen may be used as a target for cancer immunotherapy

General

glycoprotein membrane protein ring finger protein secreted protein

Properties

SIZE: MW = 86 kD entity length = 783 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-23} N-glycosylation site {N62} N-glycosylation site {N92} transmembrane domain {198-218} RING-finger {272-313} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif serine-rich region {443-503} MOTIF: serine residue (SEVERAL) histidine-rich region {547-557} MOTIF: histidine residue (SEVERAL) proline-rich region SITE: 569-760 MOTIF: proline residue (SEVERAL)

Database Correlations

UniProt Q68DV7 Pfam PF00097

References

UniProt :accession Q68DV7