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RING finger protein 13; E3 ubiquitin-protein ligase RNF13 (RNF13 RZF)
Function:
- E3 ubiquitin-protein ligase
- may play a role in controlling cell proliferation
- protein modification; protein ubiquitination
- auto-ubiquitinated
Structure:
- the RING-type Zn+2 finger domain is required for E3 ligase activity
- contains 1 PA (protease associated) domain
- contains 1 RING-type Zn+2 finger
Compartment:
- endoplasmic reticulum membrane
- Golgi membrane
- late endosome membrane
- lysosome membrane
- nuclear inner membrane (putative)
- under certain conditions, relocalizes to recycling endosomes & to the inner nuclear membrane
- single-pass membrane protein (putative)
Expression:
- widely expressed (at protein level)
- in normal pancreas
- expressed in islets of Langerhans
- not expressed in pancreatic ducts
- not expressed in pancreatic acini
General
glycoprotein
phosphoprotein
ring finger protein
E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
Properties
SIZE: entity length = 381 aa
MW = 43 kD
COMPARTMENT: lysosome
nuclear membrane
golgi
endoplasmic reticulum
MOTIF: signal sequence {1-34}
PA {65-160}
MOTIF: N-glycosylation site {N88}
transmembrane domain {183-203}
RING-finger {240-282}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Ser phosphorylation site {S292}
Ser phosphorylation site {S294}
Thr phosphorylation site {T296}
Ser phosphorylation site {S298}
Ser phosphorylation site {S299}
Database Correlations
OMIM 609247
UniProt O43567
Pfam PF02225
Entrez Gene 11342
Kegg hsa:11342
References
UniProt :accession O43567