bromodomain-containing protein 2; protein RING3; O27.1.1 (BRD2, KIAA9001, RING3)

Function: - may play a role in spermatogenesis or folliculogenesis - interacts with E2F1 & with histone H4 acetylated at Lys-13 Structure: - homodimer - one bromodomain is sufficient for a partial interaction with histone H4 acetylated at Lys-13 - contains 2 bromo domains - contains 1 ET domain Compartment: nucleus (putative) Alternative splicing: named isoforms=2

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 801 aa MW = 88 kD COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 61-64 MOTIF: proline residue (SEVERAL) bromodomain {91-163} Ser phosphorylation site {S298} Ser phosphorylation site {S301} Ser phosphorylation site {S305} Ser phosphorylation site {S320} bromodomain {364-436} serine-rich region {476-515} MOTIF: serine residue (SEVERAL) glutamate-rich region {492-506} MOTIF: glutamate residue (SEVERAL) lysine-rich region {544-566} MOTIF: lysine residue (SEVERAL) lysine-rich region {551-559} MOTIF: lysine residue (SEVERAL) nuclear translocation signal {555-559} Ser phosphorylation site {S633} glutamate-rich region {634-638} MOTIF: glutamate residue (SEVERAL) ET {638-801} MOTIF: Thr phosphorylation site {T724} serine-rich region {775-801} MOTIF: serine residue (SEVERAL) serine-rich region {775-793} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM 601540 UniProt P25440 Pfam PF00439 Entrez Gene 6046 Kegg hsa:6046

References

UniProt :accession P25440