E3 ubiquitin-protein ligase RING1; RING finger protein 1; polycomb complex protein RING1 (RING1, RNF1)

Function: - one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of Lys-119 of histone H2A, thereby playing a central role in histone code & gene regulation - H2A Lys-119 ubiquitination gives a specific tag for epigenetic transcriptional repression & participates in X chromosome inactivation of female mammals - component of polycomb group (PcG) multiprotein PRC1 complex - compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, & it may rather act as a modulator of RNF2/RING2 activity - protein modification; protein ubiquitination - part of the E2F6.com-1 complex - interacts with CBX2 & PCGF6 - component of repressive PcG BCOR complex Structure: contains 1 RING-type Zn⁺² finger Compartment: nucleus speckle Alternative splicing: named isoforms=2

General

nuclear protein phosphoprotein ring finger protein E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein

Properties

SIZE: entity length = 406 aa MW = 42 kD COMPARTMENT: cell nucleus MOTIF: silencer element SITE: 30-234 MOTIF: Ser phosphorylation site {S38} RING-finger {48-88} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif Ser phosphorylation site {S187} Ser phosphorylation site {S188} Ser phosphorylation site {S190} nuclear translocation signal {201-204} glycine-rich region {205-260} CBX2 interaction {230-406} MOTIF: glycine-rich region {314-377}

Database Correlations

OMIM 602045 UniProt Q06587 Pfam PF00097 Entrez Gene 6015 Kegg hsa:6015

References

UniProt :accession Q06587