RING1 & YY1-binding protein (death effector domain-associated factor, DED-associated factor, YY1 & E4TF1-associated factor 1, apoptin-associating protein 1, APAP-1, RYBP, DEDAF, YEAF1)

Function: 1) regulation of transcription 2) repressor of transcriptional activity of E4TF1 3) in tumor cell lines, may induce apoptosis 4) interacts with CBX2, YAF2, RING1 & RNF2 5) interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 & E4TF1B 6) together with E4TF1B & YY1, forms ternary complex Structure: - contains 1 RanBP2-type zinc finger Compartment: - nucleus, cytoplasm, primarily found in nucleus Expression: - widely expressed with highest levels in lymphoid tissues & placenta

General

nuclear protein zinc finger protein

Properties

SIZE: MW = 25 kD entity length = 228 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: Zinc finger NAME: Zinc finger SITE: 21-50 EFFECTOR-BOUND: Zn+2 proline-rich region SITE: 73-76 MOTIF: proline residue (SEVERAL) lysine-rich region {77-119} MOTIF: lysine residue (SEVERAL) binding site SITE: 143-226 FOR-BINDING-OF: GA-binding protein-beta 1 MOTIF: serine-rich region {179-214} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM 607535 UniProt Q8N488 Pfam PF00641

References

UniProt :accession Q8N488