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rimexolone (Vexol)
Tradenames: Vexol.
Indications:
1) treatment of inflammation after ocular surgery
2) treatment of anterior uveitis
Contraindications:
1) epithelial Herpes simplex keratitis (dendritic keratitis)
2) vaccinia, varicella & most other viral diseases of the cornea & conjunctiva
3) mycobacterial infection of the eye
4) fungal diseases of the eye
5) acute, purulent, untreated infections which might be masked or enhanced by glucocorticoids
Caution:
1) prolonged use has been associated with development of corneal or scleral perforation & posterior subcapsular cataracts
2) effectiveness & safety not established in children
Dosage: ophthalmic: 1 drop every 1-6 hours (1% suspension)
Suspension: 1% (5 mL, 10 mL)
Pharmacokinetics:
1) absorption through aqueous humor
2) any absorbed drug is metabolized in the liver
3) elimination in urine & feces
Monitor:
1) intraocular pressure
2) periodic examination of the lens with prolonged use
Adverse effects:
1) not common (1-10%)
- temporary mild blurred vision
2) uncommon (< 1%)
- stinging, burning of eyes, corneal thinning, increased intraocular pressure, glaucoma, damage to the optic nerve, defects in visual acuity, cataracts, secondary ocular infection
Interactions
drug interactions
drug adverse effects (more general classes)
monitor with drug (more general classes)
General
glucocorticoid
Properties
MISC-INFO: elimination route LIVER
pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Department of Veterans Affairs, VA National Formulary