ribosome biogenesis protein BOP1 (block of proliferation 1 protein, BOP1, KIAA0124)

Function: 1) required for maturation of the 25S rRNA & 5.8S rRNA 2) required for proper processing at 4 distinct sites located within the internal transcribed spacers ITS1 & ITS2 & the 3' external spacer 3) role in ribosome formation that coordinates processing of spacer regions in pre-rRNA Structure: contains 7 WD repeats Compartment: nucleus, nucleolus

General

nuclear protein phosphoprotein WD repeat protein family

Properties

SIZE: MW = 84 kD entity length = 746 aa COMPARTMENT: cell nucleus MOTIF: Thr phosphorylation site {T106} Ser phosphorylation site {S126} Ser phosphorylation site {S127} WD repeat {411-450} WD repeat {452-492} WD repeat {532-576} WD repeat {577-615} WD repeat {618-657} WD repeat {661-700} WD repeat {716-745}

Database Correlations

UniProt Q14137 PFAM correlations

References

UniProt :accession Q14137