ribosomal RNA-processing protein 8; cerebral protein 1; nucleomethylin (RRP8, KIAA0409, NML, hucep-1)

Function: - essential component of the eNoSC complex - in the complex, RRP8 binds to H3K9me2 & probably acts as a methyltransferase - its substrates are unknown Structure: - belongs to the methyltransferase superfamily, RRP8 family Compartment: - nucleus, nucleolus - localizes at rDNA locus

General

methyltransferase nuclear protein phosphoprotein

Properties

SIZE: entity length = 456 aa MW = 51 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S58} Ser phosphorylation site {S62} Ser phosphorylation site {S64} glutamate-rich region {65-70} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S104} Ser phosphorylation site {S106} Ser phosphorylation site {S124} Ser phosphorylation site {S126} Ser phosphorylation site {S171} Thr phosphorylation site {T175} Ser phosphorylation site {S176} Ser phosphorylation site {S223} active site binding site SITE: 281-281 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 316-316 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 334-334 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 346-346 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 347-347 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 363-363 FOR-BINDING-OF: S-adenosylmethionine

Database Correlations

UniProt O43159 Pfam PF05148 Entrez Gene 23378 Kegg hsa:23378 ENZYME 2.1.1._

References

UniProt :accession O43159