ribosomal protein S6 kinase delta-1; S6K-delta-1; 52 kD ribosomal protein S6 kinase; ribosomal S6 kinase-like protein with two PSK domains 118 kD protein; SPHK1-binding protein (RPS6KC1, RPK118)

Function: 1) transmits sphingosine-1 phosphate signal 2) interacts with SPHK1 & phosphatidylinositol 3-phosphate Structure: - 1st kinase domain appears to be pseudokinase domain - belongs to the protein kinase superfamily, Ser/Thr protein kinase family, S6 kinase subfamily - contains 1 MIT domain - contains 2 protein kinase domains - contains 1 PX (phox homology) domain Compartment: cytoplasm, membrane-associated, early endosomes Expression: - expressed in testis, skeletal muscle, brain, heart, placenta, kidney, liver > thymus, small intestine, lung, colon

General

nuclear protein ribosomal protein S6 kinase

Properties

SIZE: entity length = 1066 aa MW = 119 kD COMPARTMENT: cytoplasm MOTIF: PX domain {8-132} MOTIF: SH3-binding site NAME: SH3-binding site MIT {277-305} kinase domain SITE: 344-445 MOTIF: ATP-binding site NAME: ATP-binding site Ser phosphorylation site {S423} Ser phosphorylation site {S427} Ser phosphorylation site {S583} Ser phosphorylation site {S640} kinase domain SITE: 794-1056 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 801-809 ATP-binding site NAME: ATP-binding site SITE: 820-820 aspartate residue {D929} STATE: active state

Database Correlations

UniProt Q96S38 PFAM correlations Entrez Gene 26750 Kegg hsa:26750 ENZYME 2.7.11.1

References

UniProt :accession Q96S38